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Mitochondrial & mtDNA dynamics

Metabolism Image

Spatiotemporal
metabolic architecture

Metabolism Image

Mitochondrial toxins,
disease, & aging

KEY PUBLICATIONS

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Landoni, J. C.^✉, Lycas, M., Macuada, J., ... Manley, S.^✉ Landoni, J. C.^✉ et al. Pearling Drives Mitochondrial DNA Nucleoid Distribution. Science (2026) Winter, J.*, Landoni, J.C.*, Holt, K., ... Koslover, E.F., Manley, S.^✉ Winter, J.*, Landoni, J.C.* et al. Asymmetric mitochondrial trafficking maintains network morphology by balancing perinuclear biogenesis. Journal of Cell Biology (2026) Landoni, J. C.^✉, Erkul, S., Laalo, T., Goffart, S., Kivelä, R., ... Suomalainen, A.^✉ Landoni, J. C.^✉ et al. Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation. Nature Communications (2024) Landoni, J. C.*, Kleele, T.*^✉, Winter, J., Stepp, W., & Manley, S.^✉ Landoni, J. C.*, Kleele, T.* et al. Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network. Annual Review of Cell and Developmental Biology (2024) Kuukasjärvi, A.*, Landoni, J. C.*, Kaukonen, J., ... Suomalainen, A.^✉ Kuukasjärvi, A.*, Landoni, J. C.* et al. IMPDH2: A new gene associated with dominant juvenile-onset dystonia-tremor disorder. European Journal of Human Genetics (2021) Hämäläinen, R. H., Landoni, J. C.*, Ahlqvist, K. J.*, ... Suomalainen, A.^✉ Hämäläinen, R. H., Landoni, J. C.* et al. MtDNA replication defects challenge nuclear genome stability and provide a unifying mechanism for mouse progerias. Nature Metabolism (2019)

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